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Normally, the amountof renin in plasma acts as the limiting factor forAng II generation. In contrast totrimethoprim, it has very poor action on bacterialDHFRase

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The specificity of MPP+for dopamineneurons relates to its ability to be efficiently transportedfrom outside the neuron into the neuron through the dopa-mine transporter. According to WHO, the globalweighted mean of any INH resistance (excludingMDR) among new TB patients is 7.4%

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